Connective Tissue Diseases on the Elderly Population in Dakar Hospital Setting

Introduction: Immunosenescence contributes to the development of auto-antibodies. However, while prevalence some autoantibodies increases with age, incidence connective tissue diseases decreases age. This study aims determine clinical and paraclinical characteristics in elderly population. Materials Methods: We conducted a retrospective descriptive study, from March 2010 2021, Internal Medicine Department Aristide Le Dantec Hospital, including all medical records patients followed up for disease whose symptomatology began at an age greater than or equal 65 years. Epidemiological, clinical, paraclinical, therapeutic evolutionary data were collected pre-established survey form then processed using SPSS software. Results: Overall, 22 cases out 275 seen on consultation. They involved 16 women 6 men, aged between 85 years median 70 The mean duration picture was 15.7 months extremes 1 96 months. symptoms joint pain 21 associated dry eye mouth syndrome seven one patient underwent isolated syndrome. Joint involvement deforming 13 patients. Poor general condition noted 20 Biology showed anemia 14 patients, hyperleukocytosis (2 patients) thrombocytosis (5 patients). sedimentation rate (SR) accelerated 9 C-reactive protein (CRP) positive 12 Immunology Latex test (3 patients/6), Waaler-Rose reaction (8 patients/13), anti-cyclic citrullinated peptides (anti-CCP) antibodies (11 patients/11), anti-nuclear patients/4). Anti-extractable nuclear antigens (anti-ENA) antibody testing 4 anti-U1RNP (1 case), anti-SSA anti-SSB case). Plain X-Rays hands, wrists feet destructive lesions diagnosis rheumatoid arthritis (RA) set which Sjogren’s (SS) primary Treatment based prednisone (21 cases), methotrexate (17 patients), hydroxychloroquine (9 evolution remarkable 10 Conclusion: Autoimmune are uncommon compared young adult In our we only found As population ages, may be increasingly diagnosed.